Helical antimicrobial polypeptides with radial amphiphilicity.

  title={Helical antimicrobial polypeptides with radial amphiphilicity.},
  author={Menghua Xiong and Michelle W Lee and Rachael A Mansbach and Ziyuan Song and Yan Bao and Richard M Peek and Catherine Yao and Lin-Feng Chen and Andrew L. Ferguson and Gerard C. L. Wong and Jianjun Cheng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 43},
α-Helical antimicrobial peptides (AMPs) generally have facially amphiphilic structures that may lead to undesired peptide interactions with blood proteins and self-aggregation due to exposed hydrophobic surfaces. Here we report the design of a class of cationic, helical homo-polypeptide antimicrobials with a hydrophobic internal helical core and a charged… CONTINUE READING

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