Helical Apolipoproteins Stabilize ATP-binding Cassette Transporter A1 by Protecting It from Thiol Protease-mediated Degradation*

@article{Arakawa2002HelicalAS,
  title={Helical Apolipoproteins Stabilize ATP-binding Cassette Transporter A1 by Protecting It from Thiol Protease-mediated Degradation*},
  author={R. Arakawa and S. Yokoyama},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={22426 - 22429}
}
ATP-binding cassette transporter (ABC) A1 was increased by apolipoprotein A-I without an increase of its message in THP-1 cells. The pulse label study demonstrated that apoA-I retarded degradation of ABCA1. Similar changes were demonstrated by apoA-II, but the effect of high density lipoprotein was almost negligible on the basis of equivalent protein concentration. Thiol protease inhibitors (leupeptin andN-acetyl-Leu-Leu-norleucinal (ALLN)) increased ABCA1 and slowed its decay in the cells… Expand
163 Citations
Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I
  • 20
  • Highly Influenced
Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux
  • N. Wang, A. Tall
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular biology
  • 2003
  • 237
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
ABCA1 Is the cAMP-inducible Apolipoprotein Receptor That Mediates Cholesterol Secretion from Macrophages*
  • 519
  • PDF
ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte‐derived macrophages
  • 103
Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools.
  • 72
...
1
2
3
...