Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.

@article{Jang2013HelenalininducedAI,
  title={Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.},
  author={Ji Hoon Jang and Taha Iqbal and Kyoung-jin Min and Shin Hyoung Kim and Jong-Wook Park and E I Son and Tae-Jin Lee and Taeg Kyu Kwon},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 2},
  pages={588-96}
}
Helenalin, a sesquiterpene lactone, exhibits anti-inflammatory and anti-tumor activities. Here, we investigated whether helenalin could induce apoptosis in human renal carcinoma Caki cells. Helenalin increased apoptosis in dose dependent manner in Caki cells, and also induced apoptosis in other carcinoma cells, such as human renal carcinoma ACHN cells, human colon carcinoma HT29 and HCT116 cells. We found that helenalin markedly induced endoplasmic reticulum (ER) stress-related genes, such as… CONTINUE READING