Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

@article{Huerta1993HeightenedSP,
  title={Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state},
  author={Patriclo T. Huerta and John E. Lisman},
  journal={Nature},
  year={1993},
  volume={364},
  pages={723-725}
}

• Patriclo T. Huerta, John E. Lisman
• Published 1993 in Nature
• DOI:10.1038/364723a0

BRAIN cholinergic neurons are critical for memory function1,2 and their loss may contribute to memory impairment in Alzheimer's disease3. One role of cholinergic neurons is to elicit an oscillatory activity called theta rhythm4 in the hippocampus, a brain region involved in memory processing5. Theta rhythm occurs during periods of learning6,7, but its effect on the synaptic plasticity that underlies learning remains unclear. We have studied synaptic plasticity in hippocampal slices during theta… CONTINUE READING

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