Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

@article{Huerta1993HeightenedSP,
  title={Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state},
  author={P T Huerta and John E. Lisman},
  journal={Nature},
  year={1993},
  volume={364},
  pages={723-725}
}
BRAIN cholinergic neurons are critical for memory function1,2 and their loss may contribute to memory impairment in Alzheimer's disease3. One role of cholinergic neurons is to elicit an oscillatory activity called theta rhythm4 in the hippocampus, a brain region involved in memory processing5. Theta rhythm occurs during periods of learning6,7, but its effect on the synaptic plasticity that underlies learning remains unclear. We have studied synaptic plasticity in hippocampal slices during theta… 
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  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
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TLDR
The existing knowledge in the field is summarized, protocols that can be used to induce LTP in seven major excitatory synaptic pathways in hippocampal slices are described, and a procedure to investigate synaptic plasticity and induce high-frequency oscillations under one experimental paradigm is introduced.
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  • D. Debanne
  • Biology
    Reviews in the neurosciences
  • 1996
TLDR
The role of postsynaptic calcium as a key parameter in the encoding of temporal contiguity of neural activity and its possible implications in the formation of engrams during specific learning tasks are discussed.
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