• DOI:10.1038/364723A0
• Corpus ID: 4358000

Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

@article{Huerta1993HeightenedSP,
  title={Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state},
  author={P T Huerta and John E. Lisman},
  journal={Nature},
  year={1993},
  volume={364},
  pages={723-725}
}

• P. T. Huerta, J. Lisman
• Published 19 August 1993
• Biology, Psychology
• Nature

BRAIN cholinergic neurons are critical for memory function1,2 and their loss may contribute to memory impairment in Alzheimer's disease3. One role of cholinergic neurons is to elicit an oscillatory activity called theta rhythm4 in the hippocampus, a brain region involved in memory processing5. Theta rhythm occurs during periods of learning6,7, but its effect on the synaptic plasticity that underlies learning remains unclear. We have studied synaptic plasticity in hippocampal slices during theta-frequency oscillations induced by a cholinergic agonist8–10. Here we report that during these oscillations, synapses are in a state of heightened plasticity and can be modified by what would otherwise be ineffective stimulation. This heightened plasticity is sensitive to the timing of incoming stimuli with respect to the oscillatory activity. The results suggest that cholinergic systems may affect memory formation through the induction of an oscillatory state in which the requirements for synaptic plasticity are dramatically altered.