Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease.

  title={Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease.},
  author={Moad K Sharief and Alison Green and Judith P. Dick and Jeffrey Gawler and Edward J. Thompson},
  volume={52 6},
The authors report high intrathecal release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-alpha and IL-1beta was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines. 

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