Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

@inproceedings{Quirke2014HeightenedIR,
  title={Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis},
  author={Anne-Marie Quirke and Elena Birgitta Lugli and Natalia Wegner and Bart C Hamilton and Peter J. Charles and Muslima Chowdhury and Anders Jimmy Ytterberg and Roman A. Zubarev and Jan Potempa and Shauna Culshaw and Yonghua Guo and Benjamin A Fisher and Geoffrey M Thiele and Ted R Mikuls and Patrick J W Venables},
  booktitle={Annals of the rheumatic diseases},
  year={2014}
}
BACKGROUND Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA. P gingivalis is apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylarginine deiminase (PPAD) with the potential to generate antigens driving the autoimmune response. OBJECTIVES To examine the immune response to PPAD in patients with RA, individuals with periodontitis (PD… CONTINUE READING
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