Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner.

Abstract

We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and progesterone (P4) are essential for this response. However, to what extent testosterone may also contribute, and whether duration of response to ketamine is modulated in a sex- and… (More)
DOI: 10.1038/srep21322

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