Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state.

@article{Liu2022HedgehogSR,
  title={Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state.},
  author={Ying-zi Liu and Christian F. Guerrero-Juarez and Fei Xiao and Nitish Udupi Shettigar and Raul Ramos and Chen-Hsiang Kuan and Yuh-Charn Lin and Luis de Jesus Martinez Lomeli and Jung Min Park and Ji Won Oh and Ruiqi Liu and Sung-Jan Lin and Marco Tartaglia and Ruey-Bing Yang and Zhengquan Yu and Qing Nie and Ji Li and Maksim V. Plikus},
  journal={Developmental cell},
  year={2022}
}
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References

SHOWING 1-10 OF 105 REFERENCES

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop.

It is suggested that dermal Shh signaling regulates specific DP signatures to maintain DP maturation while maintaining a reciprocal Shh-Noggin signaling loop to drive hair follicle morphogenesis.

Coordinated hedgehog signaling induces new hair follicles in adult skin

It is revealed that activation of Hedgehog signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal mouse skin, thereby inducing complex epithelial structures even without wounding.

Essential role for Sonic hedgehog during hair follicle morphogenesis.

An obligatory role for the secreted morphogen Sonic hedgehog (Shh) during hair follicle development is reported, where it is required for normal advancement beyond the hair germ stage of development.

Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

It is demonstrated that induced expression of a stabilized form of β-catenin in CD133+ DP cells significantly accelerates spontaneous and depilation-induced hair growth and potentiates the capability of CD133 + DP cells to promote postnatal hair growth.

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

The fate analysis of HFSCs during aging revealed that organ aging is primed by the sustained DNA damage response against DNA damage that accumulates in renewing stem cells during aging.

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties.

Results reveal that BMP signaling, in addition to its key role in epithelial stem cell maintenance and progenitor cell differentiation, is essential for DP cell function, and suggest that it is a critical feature of the complex epithelial-mesenchymal cross-talk necessary to make hair.

Sonic hedgehog signaling is essential for hair development

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway.

The results suggest that the topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant follicular cycling in the scalp including androgenetic alopecia (pattern hair loss).
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