Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.

Abstract

In many organ systems such as the skin, gastrointestinal tract and hematopoietic system, homeostasis is dependent on the continuous generation of differentiated progeny from stem cells. The rodent incisor, unlike human teeth, grows throughout the life of the animal and provides a prime example of an organ that rapidly deteriorates if newly differentiated… (More)
DOI: 10.1242/dev.056358

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