Hedgehog signaling promotes medulloblastoma survival via Bc/II.

  title={Hedgehog signaling promotes medulloblastoma survival via Bc/II.},
  author={Eli E Bar and Aneeka G Chaudhry and Mohamed Farah and Charles G. Eberhart},
  journal={The American journal of pathology},
  volume={170 1},
Activation of the Hedgehog (Hh) pathway has been identified in several cancers, including medulloblastoma, but the mechanisms by which this pathway affects tumor survival and growth are incompletely understood. We investigated whether Hedgehog might promote survival of medulloblastoma cells via up-regulation of BclII. We found that mRNA levels of the Hedgehog pathway effector Gli1 were significantly associated with BclII expression in medulloblastoma and that Gli1 and BclII are both present in… CONTINUE READING

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