Hedgehog signaling maintains resident hepatic progenitors throughout life.

  title={Hedgehog signaling maintains resident hepatic progenitors throughout life.},
  author={Jason Sicklick and Yinxiong Li and Alaa Melhem and Eva Schmelzer and Marzena Zdanowicz and Jiawen Huang and M. A. Cabajo Caballero and Jeff H Fair and John W. Ludlow and Randall E. McClelland and Lola C. M. Reid and Anna Mae Diehl},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={290 5},
Hedgehog signaling through its receptor, Patched, activates transcription of genes, including Patched, that regulate the fate of various progenitors. Although Hedgehog signaling is required for endodermal commitment and hepatogenesis, the possibility that it regulates liver turnover in adults had not been considered because mature liver epithelial cells lack Hedgehog signaling. Herein, we show that this pathway is essential throughout life for maintaining hepatic progenitors. Patched-expressing… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 93 extracted citations

The hedgehog pathway in nonalcoholic fatty liver disease.

Critical reviews in biochemistry and molecular biology • 2018

The diversity and plasticity of adult hepatic progenitor cells and their niche.

Liver international : official journal of the International Association for the Study of the Liver • 2017


Publications referenced by this paper.
Showing 1-10 of 73 references

Hepatic stem cells and the liver’s maturational lineages. In: Adult Stem Cells, edited by Potten CS

E Schmelzer, A Melhem, +9 authors LM. Reid
View 4 Excerpts
Highly Influenced

Hepatic stem cells and the liver ’ s maturational lineages

E Schmelzer, A Melhem, +9 authors LM Reid
Adult Stem Cells , edited by • 2006

Communicating with Hedgehogs

Nature Reviews Molecular Cell Biology • 2005
View 1 Excerpt

Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 2 Excerpts

Hedgehog signaling correlates with hepatocellular carcinoma progression (Abstract)

JK Sicklick, A Jayaraman, +3 authors AM. Diehl
J Clin Oncol • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…