Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors.

@article{Hirsinger2004HedgehogSI,
  title={Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors.},
  author={Estelle Hirsinger and Frank Stellabotte and Stephen H Devoto and Monte Westerfield},
  journal={Developmental biology},
  year={2004},
  volume={275 1},
  pages={
          143-57
        }
}
In zebrafish, skeletal muscle precursors can adopt at least three distinct fates: fast, non-pioneer slow, or pioneer slow muscle fibers. Slow muscle fibers develop from adaxial cells and depend on Hedgehog signaling. We analyzed when precursors become committed to their fates and the step(s) along their differentiation pathway affected by Hedgehog. Unexpectedly, we find that embryos deficient in Hedgehog signaling still contain postmitotic adaxial cells that differentiate into fast muscle… CONTINUE READING

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HIGHLY INFLUENTIAL