Hedgehog signaling is essential for endothelial tube formation during vasculogenesis

@inproceedings{Vokes2004HedgehogSI,
  title={Hedgehog signaling is essential for endothelial tube formation during vasculogenesis},
  author={Steven A. Vokes and Tatiana A. Yatskievych and Ronald L. Heimark and Jill A. McMahon and Andrew P. McMahon and Parker B. Antin and Paul A. Krieg},
  booktitle={Development},
  year={2004}
}
During embryonic development, the first blood vessels are formed through the aggregation and subsequent assembly of angioblasts (endothelial precursors) into a network of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble into a vascular network and to… 
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