Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons.

@article{Balordi2007HedgehogSI,
  title={Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons.},
  author={Francesca Balordi and Gordon Fishell},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 22},
  pages={
          5936-47
        }
}
We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. Although at birth the subventricular zone appears normal in mice lacking Hedgehog signaling, by postnatal day 8 it is greatly impaired, and cell death is increased. In addition, both the quiescent B stem cell population and transit-amplifying C cells become depleted postnatally. In contrast, the A cell population expands precociously, mostly fails to migrate to the olfactory bulbs, and is… CONTINUE READING
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