Hedgehog signaling in animal development: paradigms and principles.

@article{Ingham2001HedgehogSI,
  title={Hedgehog signaling in animal development: paradigms and principles.},
  author={Phillip W. Ingham and Andrew P. McMahon},
  journal={Genes \& development},
  year={2001},
  volume={15 23},
  pages={
          3059-87
        }
}
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development. Their activities are central to the growth, patterning, and morphogenesis of many different regions within the body plans of vertebrates and insects, and most likely other invertebrates. In some contexts, Hedgehog signals act as morphogens in the dose-dependent induction of distinct cell… Expand
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Interventional Clinical Trial
Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway
The purpose of this study is to evaluate the safety of vismodegib in combination with temozolomide (primary objective - phase I) and to estimate the efficacy of vismodegib in… Expand
ConditionsActivation of the Sonic Hedgehog (SHH) Pathway, Histologically Confirmed Medulloblastoma
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References

SHOWING 1-10 OF 343 REFERENCES
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
TLDR
It is found that different levels of hh activity can induce graded changes in the patterning of the wing, and that zebrafish shh acts in a similar though attenuated fashion. Expand
An absolute requirement for Cubitus interruptus in Hedgehog signaling.
TLDR
This work addresses the question of whether the Hh pathway is distally branched or, in other words, whether the regulation of Ci activity is the sole output of Hh signaling and proposes that most cases of apparent Ci/Gli-independent Hh output can be attributed to the derepression of target gene expression in the absence of Ci/gli repressor function. Expand
The sonic hedgehog-patched-gli pathway in human development and disease.
TLDR
This review focuses specifically on the current understanding of the Shh-Ptch-Gli pathway and its clinical significance in humans. Expand
Genetic analysis of hedgehog signalling in the Drosophila embryo.
TLDR
Evidence is presented that transduction of the hh-encoded signal is mediated by the activity of four other segment polarity genes, patched, fused, costal-2 and cubitus interruptus, and that transcription of patched is regulated by the same pathway. Expand
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.
TLDR
It is shown that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites, and banded hedgehog is expressed throughout the neural plate and subsequently in both the nervousSystem and in the dermatome of somites. Expand
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
TLDR
It is shown that the segment-polarity gene smoothened is required for the response of cells to hedgehog signalling during the development of both the embryonic segments and imaginal discs. Expand
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila.
TLDR
It is shown that it is required positively for rhomboid expression and that Teashirt and Ci act in a partially redundant manner before stage 11 to maintain wingless expression in the trunk. Expand
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
TLDR
It is suggested that secreted signals encoded by members of the hedgehog gene family, emanating from the ventral midline of the neural tube, not only play important roles in dorso-ventral patterning of the brain but also appear to constitute an early patterning activity along the proximo-distal axis of the developing eyes. Expand
Hedgehog signals regulate multiple aspects of gastrointestinal development.
TLDR
It is shown that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations. Expand
Hedgehog signaling is required for pituitary gland development.
TLDR
Investigation of the role of the morphogen Sonic hedgehog in outgrowth and differentiation of the pituitary gland using loss- and gain-of-function studies in transgenic mice suggests that Hedgehog signaling, together with FGF8/10 signaling, synergizes to regulate expression of the LIM homeobox gene Lhx3, which has been proved to be essential for initial pituitsary gland formation. Expand
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