Hedgehog signaling in animal development: paradigms and principles.

@article{Ingham2001HedgehogSI,
  title={Hedgehog signaling in animal development: paradigms and principles.},
  author={Phillip W. Ingham and Andrew P. McMahon},
  journal={Genes \& development},
  year={2001},
  volume={15 23},
  pages={
          3059-87
        }
}
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development. Their activities are central to the growth, patterning, and morphogenesis of many different regions within the body plans of vertebrates and insects, and most likely other invertebrates. In some contexts, Hedgehog signals act as morphogens in the dose-dependent induction of distinct cell… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to evaluate the safety of vismodegib in combination with temozolomide (primary objective - phase I) and to estimate the efficacy of vismodegib in… Expand
ConditionsActivation of the Sonic Hedgehog (SHH) Pathway, Histologically Confirmed Medulloblastoma
InterventionDrug
Cholesterol modification of Hedgehog family proteins.
TLDR
Several pieces of evidence support the notion that this patterning of larval wing imaginal discs is mediated by a direct morphogen activity of Shh, and the cell-autonomous activation or inactivation of the pathway using mutant forms of receptor components results in autonomous changes of cell fates, confirming the direct role of Hh signaling. Expand
Regulation of the Hedgehog Morphogene Gradient
TLDR
This review will discuss recent progresses in the understanding of Hh ligand packaging and dispatch from producing cells and its consequences for gradient formation. Expand
Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction1
TLDR
Hh signaling has been recognized during embryonic development and in some cases during postnatal life in several mammalian tissues whose functions are essential for reproduction, including the gonads, uterus, and hormonally responsive accessory sex glands such as the prostate and mammary gland. Expand
The adventures of sonic hedgehog in development and repair. III. Hedgehog processing and biological activity.
TLDR
This review is intended to give a broad overview of how the biosynthesis and movement of Hh contributes to its biological activity. Expand
Sending and Receiving Hedgehog Signals.
TLDR
This review examines the unique biosynthesis of the Hedgehog ligand, its specialized release from cells into extracellular space, and the poorly understood mechanisms involved in ligand reception and pathway activation at the surface of target cells. Expand
The emerging roles of phosphatases in Hedgehog pathway
TLDR
A summary of current progress on phosphatase studies in Hedgehog pathway is presented, emphasizing the multiple employments of protein serine/threonine phosphatases during the transduction of morphogenic Hedgehog signal in both Drosophila and vertebrate systems, all of which provide insights into the importance ofosphatases in the specific regulation of Hedgehog signaling. Expand
Conserved molecular paradigms pattern smooth muscle in urogenital development.
  • W. Bushman
  • Biology, Medicine
  • The Journal of urology
  • 2008
TLDR
Cheng et al present evidence suggesting that Shh signaling from the epithelium of the developing bladder is associated with restricted expression of the Ci homolog Gli2 and Bmp4 in the adjacent mesenchyme, and that this is responsible for the patterning of bladder wall development with an outer layer of smooth muscles and an inner layer of fibroblastic stroma. Expand
Hedgehog Secretion and Signal Transduction in Vertebrates
TLDR
This minireview will provide an overview of Hh signaling and present recent insights into vertebrate Hh secretion, receptor binding, and signal transduction. Expand
Hedgehog Signaling
TLDR
This review examines various examples in which biophysical and biomechanical aspects of hedgehog signaling in development are revealed, including the own data using the mouse whole embryo culture system. Expand
Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis.
TLDR
An overview of the role of constitutively active aberrant HH signaling pathway in different types of human cancer and the underlying molecular and genetic mechanisms that drive tumorigenesis in that particular tissue is provided. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 343 REFERENCES
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
TLDR
It is found that different levels of hh activity can induce graded changes in the patterning of the wing, and that zebrafish shh acts in a similar though attenuated fashion. Expand
An absolute requirement for Cubitus interruptus in Hedgehog signaling.
TLDR
This work addresses the question of whether the Hh pathway is distally branched or, in other words, whether the regulation of Ci activity is the sole output of Hh signaling and proposes that most cases of apparent Ci/Gli-independent Hh output can be attributed to the derepression of target gene expression in the absence of Ci/gli repressor function. Expand
The sonic hedgehog-patched-gli pathway in human development and disease.
TLDR
This review focuses specifically on the current understanding of the Shh-Ptch-Gli pathway and its clinical significance in humans. Expand
Genetic analysis of hedgehog signalling in the Drosophila embryo.
TLDR
Evidence is presented that transduction of the hh-encoded signal is mediated by the activity of four other segment polarity genes, patched, fused, costal-2 and cubitus interruptus, and that transcription of patched is regulated by the same pathway. Expand
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.
TLDR
It is shown that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites, and banded hedgehog is expressed throughout the neural plate and subsequently in both the nervousSystem and in the dermatome of somites. Expand
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
TLDR
It is shown that the segment-polarity gene smoothened is required for the response of cells to hedgehog signalling during the development of both the embryonic segments and imaginal discs. Expand
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila.
TLDR
It is shown that it is required positively for rhomboid expression and that Teashirt and Ci act in a partially redundant manner before stage 11 to maintain wingless expression in the trunk. Expand
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
TLDR
It is suggested that secreted signals encoded by members of the hedgehog gene family, emanating from the ventral midline of the neural tube, not only play important roles in dorso-ventral patterning of the brain but also appear to constitute an early patterning activity along the proximo-distal axis of the developing eyes. Expand
Hedgehog signals regulate multiple aspects of gastrointestinal development.
TLDR
It is shown that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations. Expand
Hedgehog signaling is required for pituitary gland development.
TLDR
Investigation of the role of the morphogen Sonic hedgehog in outgrowth and differentiation of the pituitary gland using loss- and gain-of-function studies in transgenic mice suggests that Hedgehog signaling, together with FGF8/10 signaling, synergizes to regulate expression of the LIM homeobox gene Lhx3, which has been proved to be essential for initial pituitsary gland formation. Expand
...
1
2
3
4
5
...