Hedgehog signaling in animal development: paradigms and principles.

@article{Ingham2001HedgehogSI,
  title={Hedgehog signaling in animal development: paradigms and principles.},
  author={Phillip W. Ingham and Andrew P. McMahon},
  journal={Genes \& development},
  year={2001},
  volume={15 23},
  pages={
          3059-87
        }
}
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development. Their activities are central to the growth, patterning, and morphogenesis of many different regions within the body plans of vertebrates and insects, and most likely other invertebrates. In some contexts, Hedgehog signals act as morphogens in the dose-dependent induction of distinct cell… 

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