Hedgehog signaling from the ZLI regulates diencephalic regional identity

  title={Hedgehog signaling from the ZLI regulates diencephalic regional identity},
  author={C. Kiecker and A. Lumsden},
  journal={Nature Neuroscience},
  • C. Kiecker, A. Lumsden
  • Published 2004
  • Biology, Medicine
  • Nature Neuroscience
  • The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying a ZLI-specific role for this gene. To modulate Shh signaling in a spatiotemporally restricted manner, we carried out gain- and loss-of-function experiments in chick embryos using… CONTINUE READING
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