• DOI:10.1038/nn1338
Corpus ID: 29863625

Hedgehog signaling from the ZLI regulates diencephalic regional identity

@article{Kiecker2004HedgehogSF,
  title={Hedgehog signaling from the ZLI regulates diencephalic regional identity},
  author={C. Kiecker and A. Lumsden},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={1242-1249}
}

C. Kiecker, A. Lumsden

Published 2004

Biology, Medicine

Nature Neuroscience

The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying a ZLI-specific role for this gene. To modulate Shh signaling in a spatiotemporally restricted manner, we carried out gain- and loss-of-function experiments in chick embryos using… CONTINUE READING

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