Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.

Abstract

OBJECTIVE Hedgehog signaling not only plays crucial roles during human development but also has been implicated in the pathogenesis of several diseases in adults. The aim of the present study was to investigate the role of the hedgehog pathway in fibroblast activation in systemic sclerosis (SSc). METHODS Activation of the hedgehog pathway was analyzed by… (More)
DOI: 10.1002/art.34444

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