Hedgehog signaling and the Gli code in stem cells, cancer, and metastases.

  title={Hedgehog signaling and the Gli code in stem cells, cancer, and metastases.},
  author={Ariel Ruiz i Altaba},
  journal={Science signaling},
  volume={4 200},
The Hedgehog (Hh)-Gli signaling pathway is an essential pathway involved in development and cancer. It controls the Gli code-the sum of all activator and repressor functions of the Gli transcription factors. Through the Gli code, and Gli1 in particular, it modulates the fate and behavior of stem and cancer stem cells, as well as tumor growth and survival in many human cancer types. It also affects recurrence and metastasis and is enhanced in advanced tumors, where it promotes an embryonic stem… CONTINUE READING
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