Hedgehog signaling and pancreatic tumor development.


Numerous signaling pathways are misregulated in pancreatic ductal adenocarcinoma (PDAC), a highly malignant type of cancer. One of these is the Hedgehog (HH) pathway, which is normally involved in patterning processes in the developing embryo. Expression of the main ligand Sonic Hedgehog is an early event in carcinogenesis and correlates with the mutation… (More)
DOI: 10.1016/B978-0-12-386469-7.00001-3


Cite this paper

@article{Lauth2011HedgehogSA, title={Hedgehog signaling and pancreatic tumor development.}, author={Matthias Lauth and Rune Toftg{\aa}rd}, journal={Advances in cancer research}, year={2011}, volume={110}, pages={1-17} }