Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

@article{Rohatgi2009HedgehogST,
  title={Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.},
  author={Rajat Rohatgi and Ljiljana Milenkovic and Ryan Bruce Corcoran and Matthew P Scott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={
          3196-201
        }
}
The Hedgehog (Hh) signaling pathway controls growth, cell fate decisions, and morphogenesis during development. Damage to Hh transduction machinery can lead to birth defects and cancer. The transmembrane protein Smoothened (Smo) relays the Hh signal and is an important drug target in cancer. Smo enrichment in primary cilia is thought to drive activation of target genes. Using small-molecule agonists and antagonists to dissect Smo function, we find that Smo enrichment in cilia is not sufficient… CONTINUE READING

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