Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E

@article{DumanScheel2002HedgehogRC,
  title={Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E},
  author={Molly Duman-Scheel and Li Weng and Shijie Xin and Wei Du},
  journal={Nature},
  year={2002},
  volume={417},
  pages={299-304}
}
Although mutations that activate the Hedgehog (Hh) signalling pathway have been linked to several types of cancer, the molecular and cellular basis of Hh's ability to induce tumour formation is not well understood. We identified a mutation in patched (ptc), an inhibitor of Hh signalling, in a genetic screen for regulators of the Retinoblastoma (Rb) pathway in Drosophila. Here we show that Hh signalling promotes transcription of Cyclin E and Cyclin D, two inhibitors of Rb, and principal… CONTINUE READING
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