Hedgehog pathway and GLI1 isoforms in human cancer.

  title={Hedgehog pathway and GLI1 isoforms in human cancer.},
  author={Richard L. Carpenter and Hui-wen Lo},
  journal={Discovery medicine},
  volume={13 69},
The Hedgehog signaling pathway regulates normal cell growth and differentiation. When deregulated, the Hedgehog pathway leads to tumorigenesis and supports more aggressive phenotypes of human cancers, such as progression, metastasis, and therapeutic resistance. The glioma-associated oncogene homolog 1 (GLI1) family of zinc finger transcription factors is the nuclear mediator of the Hedgehog pathway that regulates genes essential for various stages of tumor development and progression… CONTINUE READING


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