Hedgehog pathway agonism: therapeutic potential and small-molecule development.

@article{Hadden2014HedgehogPA,
  title={Hedgehog pathway agonism: therapeutic potential and small-molecule development.},
  author={M Kyle Hadden},
  journal={ChemMedChem},
  year={2014},
  volume={9 1},
  pages={27-37}
}
The Hedgehog (Hh) pathway is a developmental signaling pathway that plays multiple roles during embryonic development and in adult tissues. Constitutive Hh signaling has been linked to the development and progression of several forms of cancer, and the application of small-molecule pathway inhibitors as anticancer chemotherapeutics is well studied and clearly defined. Activation of the Hh pathway as a therapeutic strategy for a variety of degenerative or ischemic disorders has also been… CONTINUE READING