Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis.

Abstract

The Drosophila testis harbors two types of stem cells: germ line stem cells (GSCs) and cyst stem cells (CySCs). Both stem cell types share a physical niche called the hub, located at the apical tip of the testis. The niche produces the JAK/STAT ligand Unpaired (Upd) and BMPs to maintain CySCs and GSCs, respectively. However, GSCs also require BMPs produced… (More)
DOI: 10.1242/dev.086413

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