Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4.

  title={Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4.},
  author={Jeanette Astorga and Peter Carlsson},
  volume={134 20},
The first vasculature of the developing vertebrate embryo forms by assembly of endothelial cells into simple tubes from clusters of mesodermal angioblasts. Maturation of this vasculature involves remodeling, pruning and investment with mural cells. Hedgehog proteins are part of the instructive endodermal signal that triggers the assembly of the first primitive vessels in the mesoderm. We used a combination of genetic and in vitro culture methods to investigate the role of hedgehogs and their… CONTINUE READING


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