Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice.

@article{Eichenmller2007HedgehogindependentOO,
  title={Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice.},
  author={Melanie Eichenm{\"u}ller and Regine Bauer and Dietrich von Schweinitz and Heidi Ann Hahn and Roland Kappler},
  journal={International journal of oncology},
  year={2007},
  volume={31 2},
  pages={405-12}
}
The tumor suppressor gene PATCHED1 (PTCH1) is a member of the hedgehog signaling pathway and causatively associated with several human sporadic and familial cancers, including those of the skin, muscle and brain. Inactivation of one Ptch1 allele in the mouse results in the development of medulloblastoma and rhabdomyosarcoma (RMS), the latter being a… CONTINUE READING