Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus.

@article{Isohata2009HedgehogAE,
  title={Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus.},
  author={Noriyuki Isohata and Kazuhiko Aoyagi and Tomoko Mabuchi and Hiroyuki Daiko and Masahide Fukaya and Hiroyuki Ohta and Kenji Ogawa and Teruhiko Yoshida and Hiroki Sasaki},
  journal={International journal of cancer},
  year={2009},
  volume={125 5},
  pages={1212-21}
}
It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells in the esophagus. By laser microdissection (LMD)-based microarray and reverse transcription polymerase chain reaction in the undifferentiated and differentiated epithelial cells of… CONTINUE READING

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