Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation.

  title={Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation.},
  author={Xuesong Feng and E. Adiarte and S. Devoto},
  journal={Developmental biology},
  volume={300 2},
  • Xuesong Feng, E. Adiarte, S. Devoto
  • Published 2006
  • Biology, Medicine
  • Developmental biology
  • Vertebrate myogenesis is regulated by signaling proteins secreted from surrounding tissues. One of the most important, Sonic hedgehog, has been proposed to regulate myogenic precursor cell survival, proliferation, and differentiation in a variety of vertebrates. In zebrafish, Hedgehog signaling is both necessary and sufficient for the development of embryonic slow muscle fibers-the earliest differentiating muscle fibers. Here we investigated the function of Hedgehog signaling in another… CONTINUE READING

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    Hedgehog signaling in animal development: paradigms and principles.
    • 2,675
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    Sonic hedgehog controls epaxial muscle determination through Myf5 activation.
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    • 913
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    The formation of skeletal muscle: from somite to limb
    • 740
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    • 342
    • Highly Influential
    • Open Access