Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.

@article{Omenetti2011HedgehogAE,
  title={Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.},
  author={Alessia Omenetti and Lee M. Bass and Robert Albert Anders and Maria Grazia Clemente and Heather Francis and Cynthia D. Guy and Shannon McCall and Steve Choi and Gianfranco D Alpini and Kathleen B. Schwarz and Anna Mae Diehl and Peter F. Whitington},
  journal={Hepatology},
  year={2011},
  volume={53 4},
  pages={1246-58}
}
UNLABELLED Biliary atresia (BA) is notable for marked ductular reaction and rapid development of fibrosis. Activation of the Hedgehog (Hh) pathway promotes the expansion of populations of immature epithelial cells that coexpress mesenchymal markers and may be profibrogenic. We examined the hypothesis that in BA excessive Hh activation impedes ductular morphogenesis and enhances fibrogenesis by promoting accumulation of immature ductular cells with a mesenchymal phenotype. Livers and remnant… CONTINUE READING

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Sonic hedgehog pathway

  • A Ominetti, AM Diehl
  • eds. Singaling Pathways in Liver Diseases
  • 2009
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