Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses.

@article{Zhou2011HedgehogAF,
  title={Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses.},
  author={Qianhe Zhou and Daniel Kalderon},
  journal={Developmental cell},
  year={2011},
  volume={20 6},
  pages={802-14}
}
In flies and mammals, extracellular Hedgehog (Hh) molecules alter cell fates and proliferation by regulating the levels and activities of Ci/Gli family transcription factors. How Hh-induced activation of transmembrane Smoothened (Smo) proteins reverses Ci/Gli inhibition by Suppressor of Fused (SuFu) and kinesin family protein (Cos2/Kif7) binding partners is a major unanswered question. Here we show that the Fused (Fu) protein kinase is activated by Smo and Cos2 via Fu- and CK1-dependent… CONTINUE READING

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