Hedgehog Signaling Regulates MyoD Expression and Activity*

  title={Hedgehog Signaling Regulates MyoD Expression and Activity*},
  author={Anastassia Voronova and Erin Coyne and Ashraf Said Al Madhoun and Joel Vincent Fair and Neven Bosiljcic and Catherine St-Louis and Grace Li and Sherry Thurig and Valerie A Wallace and Nadine Wiper-Bergeron and Ilona Sylvia Skerjanc},
  booktitle={The Journal of biological chemistry},
The inhibition of MyoD expression is important for obtaining muscle progenitors that can replenish the satellite cell niche during muscle repair. Progenitors could be derived from either embryonic stem cells or satellite cells. Hedgehog (Hh) signaling is important for MyoD expression during embryogenesis and adult muscle regeneration. To date, the mechanistic understanding of MyoD regulation by Hh signaling is unclear. Here, we demonstrate that the Hh effector, Gli2, regulates MyoD expression… CONTINUE READING
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