Hedgehog Signaling: Measuring Ligand Concentrations with Receptor Ratios

Abstract

How the binding of Hedgehog to its receptor, Patched, initiates signaling is poorly understood. A recent study suggests a mechanism by which the ratio of unliganded to liganded Patched determines the cellular response.

DOI: 10.1016/j.cub.2004.09.071

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@article{Briscoe2004HedgehogSM, title={Hedgehog Signaling: Measuring Ligand Concentrations with Receptor Ratios}, author={James Briscoe}, journal={Current Biology}, year={2004}, volume={14}, pages={R889-R891} }