Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?

Abstract

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal. 
DOI: 10.1016/j.cub.2008.12.010

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