Hedgehog Signaling: A Smoothened Conformational Switch

Abstract

An intracellular conformational switch in the serpentine transmembrane protein Smoothened appears to underlie Hedgehog pathway activation. The switch is gated by electrostatic interactions that are regulated by multiple phosphorylations, potentially endowing a dose-dependent response. 
DOI: 10.1016/j.cub.2007.11.035

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