Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

@article{Denef2000HedgehogIO,
  title={Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened},
  author={Natalie Denef and Dagmar Neubueser and Lidia Mart{\'i}nez P{\'e}rez and Stephen Michael Cohen},
  journal={Cell},
  year={2000},
  volume={102},
  pages={521-531}
}
Secreted signaling proteins of the Hedgehog family organize spatial pattern during animal development. Two integral membrane proteins have been identified with distinct roles in Hedgehog signaling. Patched functions in Hedgehog binding, and Smoothened functions in transducing the signal. Current models view Patched and Smoothened as a preformed receptor complex that is activated by Hedgehog binding. Here we present evidence that Patched destabilizes Smoothened in the absence of Hedgehog… CONTINUE READING
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