Hedgehog-Induced Medulloblastomas Critical for the Growth and Survival of Sonic The SmoA1 Mouse Model Reveals That Notch Signaling Is


To develop a genetically faithful model of medulloblastoma with increased tumor incidence compared with the current best model we activated the Sonic Hedgehog (Shh) pathway by transgenically expressing a constitutively active form of Smoothened in mouse cerebellar granule neuron precursors (ND2:SmoA1 mice). This resulted in early cerebellar granule cell… (More)


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