Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.

@article{SimsMourtada2006HedgehogAA,
  title={Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.},
  author={Jennifer Sims-Mourtada and Julie G. Izzo and Smith Apisarnthanarax and T. T. Wu and Usha Malhotra and Rajyalashmi Luthra and Zhongxing Liao and Ritsuko Komaki and Albert J van der Kogel and Jaffer Ajani and K. S. Chao},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 21},
  pages={6565-72}
}
PURPOSE Despite aggressive chemotherapy, radiotherapy, surgery, or combination approaches, the survival rate of patients with esophageal cancer remains poor. Recent studies have suggested that constitutive activation of the Hedgehog (Hh) pathway in cancers of the digestive tract may contribute to the growth and maintenance of cancer. However, the relationship between Hh signaling and therapeutic response is unknown. EXPERIMENTAL DESIGN The expression and temporal kinetics of Hh signaling and… CONTINUE READING