Heavy water lengthens the period of free-running rhythms in lesioned hamsters bearing SCN grafts

  title={Heavy water lengthens the period of free-running rhythms in lesioned hamsters bearing SCN grafts},
  author={J. LeSauter and R. Silver},
  journal={Physiology \& Behavior},
Heavy water (D2O) lengthens the period of free-running circadian rhythms in most organisms. We compared the effect of D2O on free-running locomotor activity rhythms in intact and SCN-lesioned (SCN-X) hamsters that had recovered circadian rhythmicity following implantation of SCN grafts. The animals were housed individually in cages equipped with running wheels, and locomotor activity was monitored using a computer-based data acquisition system. At the end of the behavioral tests, animals were… Expand
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
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