Heavy water (D2O) alters the sodium channel gating current in squid giant axons.

@article{Landowne2000HeavyW,
  title={Heavy water (D2O) alters the sodium channel gating current in squid giant axons.},
  author={David Landowne},
  journal={The Biological bulletin},
  year={2000},
  volume={199 2},
  pages={164-5}
}
When nerve axon membranes are abruptly depolarized, a small outward displacement current precedes the sodium current that underlies the propagated nerve impulse. This displacement current is asymmetric; it does not appear in a symmetrical hyperpolarization. It was named “gating current” by earlier workers because of its association with the opening of the activation gates of the sodium channels. The gating currents were isolated by replacing permeant ions with impermeant ones, thus reducing… CONTINUE READING
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