Heavy metal toxicity following apical and basolateral exposure in the human intestinal cell line Caco-2.

@article{Rossi1996HeavyMT,
  title={Heavy metal toxicity following apical and basolateral exposure in the human intestinal cell line Caco-2.},
  author={Andrea M. Rossi and R. Poverini and Giulia Di Lullo and Andrea Modesti and Anna Modica and Maria Laura Scarino},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1996},
  volume={10 1},
  pages={
          27-36
        }
}
Caco-2 is a cell line, derived from a human colon carcinoma, that retains the ability to differentiate in culture into absorptive intestinal cells. Caco-2 cells were used to evaluate the toxicity of three heavy metals-the essential trace elements zinc and copper, and the xenobiotic cadmium. The cells were cultivated on permeable filters until differentiated and were then exposed to the metals either from the apical (luminal) or from the basolateral (serosal) side. Toxicity was measured in dose… CONTINUE READING

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