Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat

@article{Meehan1999HeavyLE,
  title={Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat},
  author={Julia Meehan and Mariann R. Piano and R. John Solaro and John M. Kennedy},
  journal={Basic Research in Cardiology},
  year={1999},
  volume={94},
  pages={481-488}
}
Alcoholic heart muscle disease is characterized by structural changes which include chamber dilation, ventricular hypertrophy, and myocyte damage. These effects often lead to contractile dysfunction and ultimately to heart failure if alcohol consumption is not terminated. In rat models for heart failure in which heart failure is induced by pressure or volume overload, there is a shift in the myosin heavy chain (MHC) isoforms, from α to β. As a result of this MHC transition, there is typically a… CONTINUE READING