Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation.

@article{Lomakin2014HeavylightCI,
  title={Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation.},
  author={Yakov A Lomakin and Maria Yu Zakharova and Alexey V. Stepanov and Maria A Dronina and Ivan V. Smirnov and Tatyana V Bobik and Andrey Yu Pyrkov and Nina V. Tikunova and Svetlana N. Sharanova and Vitali M Boitsov and Sergey Yu Vyazmin and Marsel R Kabilov and Alexey E. Tupikin and Alexey N. Krasnov and Nadezda A. Bykova and Yulia A. Medvedeva and Marina V. Fridman and Alexander V. Favorov and Natalia A. Ponomarenko and Michael Dubina and Alexey N. Boyko and Valentin V. Vlassov and Alexey Belogurov and Alexander G Gabibov},
  journal={Molecular immunology},
  year={2014},
  volume={62 2},
  pages={
          305-14
        }
}
The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and, in particular, production of autoantibodies of different specificities. The combination of deep-sequencing technology with functional studies of antibodies selected from highly representative immunoglobulin combinatorial libraries may provide unique information on specific features in the repertoires of autoreactive B cells. Here, we have… CONTINUE READING
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