Heavy-ion-induced bystander killing of human lung cancer cells: role of gap junctional intercellular communication.

@article{Harada2009HeavyioninducedBK,
  title={Heavy-ion-induced bystander killing of human lung cancer cells: role of gap junctional intercellular communication.},
  author={Kosaku Harada and Tetsuo Nonaka and Nobuyuki Hamada and Hideyuki Sakurai and Masatoshi Hasegawa and Tomoo Funayama and Takehiko Kakizaki and Yasuhiko Kobayashi and Takashi Nakano},
  journal={Cancer science},
  year={2009},
  volume={100 4},
  pages={684-8}
}
The aim of the present study was to clarify the mechanisms of cell death induced by heavy-ion irradiation focusing on the bystander effect in human lung cancer A549 cells. In microbeam irradiation, each of 1, 5, and 25 cells under confluent cell conditions was irradiated with 1, 5, or 10 particles of carbon ions (220 MeV), and then the surviving fraction of the population was measured by a clonogenic assay in order to investigate the bystander effect of heavy-ions. In this experiment, the… CONTINUE READING