Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein.

@article{Machamer1990HeavyCB,
  title={Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein.},
  author={Carolyn E. Machamer and Robert W. Doms and David G. Bole and Ari Helenius and John K. Rose},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 12},
  pages={6879-83}
}
To investigate the function of heavy chain binding protein (BiP, GRP 78) in the endoplasmic reticulum, we have characterized its interaction with a model plasma membrane glycoprotein, the G protein of vesicular stomatitis virus. We used a panel of well characterized mutant G proteins and immunoprecipitation with anti-BiP antibodies to determine if BiP interacted with newly synthesized G protein and/or mutant G proteins retained in the endoplasmic reticulum. We made three major observations: 1… CONTINUE READING
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