Heavy-chain antibodies in Camelidae; a case of evolutionary innovation

@article{Nguyen2002HeavychainAI,
  title={Heavy-chain antibodies in Camelidae; a case of evolutionary innovation},
  author={Viet Nga Nguyen and Chen Su and Serge Muyldermans and Wessel van der Loo},
  journal={Immunogenetics},
  year={2002},
  volume={54},
  pages={39-47}
}
The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish (Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we evaluated the phylogenetic and phenotypic relationships among HCAbs and conventional antibodies across taxa and confirmed the current viewpoint that different groups of HCAbs have… CONTINUE READING
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