Heavily mutated coronavirus variant puts scientists on alert.

  title={Heavily mutated coronavirus variant puts scientists on alert.},
  author={Ewen Callaway},
Healthcare Workers’ SARS-CoV-2 Omicron Variant Uncertainty-Related Stress, Resilience, and Coping Strategies during the First Week of the World Health Organization’s Alert
The negative association between resilient coping and stress was clearly shown, as well as how underlying intolerance of uncertainty is linked to higher stress among HCWs quickly following the development of a new infectious threat.
SARS-CoV-2: Recent Variants and Clinical Efficacy of Antibody-Based Therapy
Most of the antibody-based treatments have been effective in patients with SARS-CoV-2, however, there are still significant challenges in verifying independence, and the need for further clinical evaluation.
Emergency SARS-CoV-2 Variants of Concern: Novel Multiplex Real-Time RT-PCR Assay for Rapid Detection and Surveillance
A novel multiplex real-time reverse transcriptase PCR (RT-PCR) method was designed to detect SARS-CoV-2 variants with S gene mutations and provided an open-source PCR assay which could rapidly be deployed in laboratories around the world to enhance surveillance for the local emergence and spread of B.1.617.2 in the third Taiwan wave outbreak.
Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins
SARS-CoV-2 infection and/or Wuhan-Hu-1 mRNA vaccination produces a diverse collection of memory B cells that produce anti-NTD antibodies some of which can neutralize variants of concern, including omicron.
SARS-COV-2 Variants: Differences and Potential of Immune Evasion
This review addressed the following critical points concerning VOCs: characteristics of the SARS-CoV-2 V OCs with mutations in the S gene, possible evasion of variants from neutralizing antibodies generated through vaccination, previous infection, or immune therapies, potential risk of new pandemic waves induced by the variants worldwide, and perspectives for further studies and actions.
A Computational Dissection of Spike protein of SARS-CoV-2 Omicron Variant
The results indicate that the involvement of polar and charged residues in the interactions with ACE2 may have an impact on increased transmissibility of omicron variant.
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
This review summarized the molecular characteristics, immune evasion, and impacts of the SARS-CoV-2 variants and focused on the parallel comparison of different variants in mutational profile, transmissibility and tropism alteration, treatment effectiveness, and clinical manifestations, in order to provide a comprehensive landscape for SARs-Cov-2 variant research.
Deciphering the Impact of Mutations on the Binding Efficacy of SARS-CoV-2 Omicron and Delta Variants With Human ACE2 Receptor
A comparative interfacial binding pattern of SARS-CoV-2 spike RBD of wild type, Delta, and Omicron with the human ACE2 receptor is explored to determine the crucial determinants at the atomistic level, using MD simulation and MM/GBSA energy calculations.
The Biological Functions and Clinical Significance of SARS-CoV-2 Variants of Corcern
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve, emerging novel variants with spike protein mutations. Although most mutations emerged in the SARS-CoV-2 genome