Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.

@article{Benhnia2009HeavilyIP,
  title={Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.},
  author={Mohammed Rafii-El-idrissi Benhnia and Megan M. McCausland and John Laudenslager and Steven W. Granger and Sandra Rickert and Lilia K. Koriazova and Tomoyuki Tahara and Ralph T. Kubo and Shinichiro Kato and Shane Crotty},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12355-67}
}
Antibodies against the extracellular virion (EV or EEV) form of vaccinia virus are an important component of protective immunity in animal models and likely contribute to the protection of immunized humans against poxviruses. Using fully human monoclonal antibodies (MAbs), we now have shown that the protective attributes of the human anti-B5 antibody response to the smallpox vaccine (vaccinia virus) are heavily dependent on effector functions. By switching Fc domains of a single MAb, we have… CONTINUE READING