Heavier‐than‐air flying machines are impossible

@article{Oliveira2004HeavierthanairFM,
  title={Heavier‐than‐air flying machines are impossible},
  author={L. Oliveira and Tim Hulsen and D Lutje Hulsik and A. C. M. Paiva and Gerrit Vriend},
  journal={FEBS Letters},
  year={2004},
  volume={564}
}
An overview of recent developments in GPCR modelling: methods and validation
TLDR
In this review the most common HM computational steps are reported and discussed together with the most recent alternative approaches and main validation methods.
Molecular modeling of adenosine receptors: new results and trends
TLDR
The publication of the first high‐resolution crystal structure for bovine rhodopsin (bRh), a GPCR superfamily member, provides the option of utilizing HM to generate 3D models based on detailed structural information.
Molecular Modeling of Vasopressin V2 Receptor Tetramer in Hydrated Lipid Membrane
TLDR
This is the first Molecular Dynamics simulation of the tetramer model of a GPCR other than rhodopsin, and the optimal adjusting of monomers in lipid membrane surrounding was the purpose of simulation.
Alpha-Bulges in G Protein-Coupled Receptors
TLDR
The role of these α-bulges in ligand and G-protein binding, as well as their role in several aspects of the mobility associated with GPCR activation, are drawn attention.
Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models
TLDR
A systematic analysis of GPCR crystal structures and a consistent method for identifying suitable templates for G PCR homology modelling that will help to produce more reliable three-dimensional models are provided.
How a small change in retinal leads to G‐protein activation: Initial events suggested by molecular dynamics calculations
TLDR
This study creates an energetically unstable retinal in the light activated state and uses molecular dynamics simulations to examine the types of compensation, relaxation, and conformational changes that occur following the cis–trans light activation of Rhodopsin.
Data integration in the life sciences. A protein family-based approach.
TLDR
The GPCRDB is a data source that holds a large amount of heterogeneous data in a well-organized and easily accessible form that facilitates inferring new information using a wide spectrum of bioinformatics techniques.
GPCRs: Past, present, and future
TLDR
This chapter provides an overview of the major developments in the GPCR field since the 19th century, and sheds some light on some of the questions that are relevant now and those that need to be answered in the future regarding G PCR structure and function.
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It is found that the predicted structure of β1-adrenergic receptor leads to a binding site for epinephrine that agrees well with the mutation experiments, and the predicted binding sites and affinities for endothelial differential gene 6, mouse and rat I7 olfactory receptors, and human sweet receptor are consistent with the available experimental data.
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Rhodopsins, the photoreceptors in rod cells, are G-protein-coupled receptors with seven hydrophobic segments containing characteristic conserved sequence patterns that define a large family,. Members
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