Heavier‐than‐air flying machines are impossible

@article{Oliveira2004HeavierthanairFM,
  title={Heavier‐than‐air flying machines are impossible},
  author={L. Oliveira and Tim Hulsen and D. Lutje Hulsik and A. Paiva and G. Vriend},
  journal={FEBS Letters},
  year={2004},
  volume={564}
}
Many G protein‐coupled receptor (GPCR) models have been built over the years. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn more about the models we build today. We conclude that the GPCR modelling field is riddled with ‘common knowledge’ similar to Lord Kelvin's remark in 1895 that “heavier‐than‐air flying machines are impossible”, and we summarize what we think are the (im)possibilities of modelling GPCRs using… Expand

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References

SHOWING 1-10 OF 74 REFERENCES
Prediction of structure and function of G protein-coupled receptors
GPCRDB: an information system for G protein-coupled receptors.
Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes*
A common motif in G-protein-coupled seven transmembrane helix receptors
...
1
2
3
4
5
...