Heating treatments affect the thermal behaviour of doxorubicin loaded in PEGylated liposomes.

@article{Perinelli2017HeatingTA,
  title={Heating treatments affect the thermal behaviour of doxorubicin loaded in PEGylated liposomes.},
  author={D. R. Perinelli and M. Cespi and G. Bonacucina and F. Rendina and G. Palmieri},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={534 1-2},
  pages={
          81-88
        }
}
Doxil® is a stealth marketed PEGylated liposomal formulation, containing the anticancer drug doxorubicin. After loading via a pH gradient, fibrillar supramolecular structures of doxorubicin sulfate originates inside the core of the liposomes. Recently, the crystallinity of doxorubicin sulfate has been confirmed by high-resolution calorimetry. However, no detailed information are available on the nature of doxorubicin sulfate nanocrystals and on the effect of different thermal treatments. Thus… Expand
Effect of the concentration process on unloaded and doxorubicin loaded liposomal dispersions
Continuous-Flow Production of Injectable Liposomes via a Microfluidic Approach
High-resolution ultrasonic spectroscopy

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