Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes.

@article{Callahan2006HeatSU,
  title={Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes.},
  author={Margaret K. Callahan and Elizabeth A. Wohlfert and Antoine M Menoret and Pramod K. Srivastava},
  journal={Journal of immunology},
  year={2006},
  volume={177 12},
  pages={8393-9}
}
The heat shock response is a canonical regulatory pathway by which cellular stressors such as heat and oxidative stress alter the expression of stress-responsive genes. Some of these stress-responsive genes (heat shock proteins and MHC class I (MHC I)-related chains) play a significant role in the immune system. In this study, we have investigated the impact of stimulating the heat shock response on genes involved in the MHC I presentation pathway. We report that two inducible subunits of the… CONTINUE READING